Am Fam Physician. 2024;109(6):512
Are early diagnosis and treatment of gestational diabetes mellitus in patients at high risk beneficial for neonatal and maternal outcomes?
A randomized controlled trial of 802 pregnant patients showed that screening those at high risk for gestational diabetes mellitus in early pregnancy, and treating if positive, had modest benefits. A composite adverse neonatal outcome was reduced in the early treatment group (number needed to treat [NNT] = 18). Severe maternal perineal injury was also reduced in the early treatment group (NNT = 36).
What is the treatment for acetaminophen overdose?
N-acetylcysteine is the antidote for acetaminophen toxicity. It should be administered based on the ingested dose, serum acetaminophen concentration above the threshold at 4 hours after ingestion and later (using an acetaminophen nomogram), abnormal liver biochemistry, or evidence of liver failure attributable to an overdose.
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