Am Fam Physician. 2024;110(6):571
Does brexpiprazole (Rexulti) reduce agitation in adults with Alzheimer disease and agitated behaviors?
In a randomized, double-blind, industry-funded trial of 345 patients with Alzheimer disease and agitated behaviors, brexpiprazole modestly reduced agitation scores and was well tolerated.
What pharmacologic therapy may be used to treat chronic refractory cough?
A trial of a neuromodulator, such as gabapentin or amitriptyline, should be considered for chronic refractory cough when the underlying etiology is cough hypersensitivity.
How should chronic cough be evaluated and treated?
In adults, evaluation and treatment of chronic cough should be based on the most common causes, including upper airway cough syndrome, asthma, nonasthmatic eosinophilic bronchitis, gastroesophageal reflux disease (GERD), and laryngopharyngeal reflux. In children, the most common causes include protracted bacterial bronchitis, asthma, bronchiectasis, upper airway cough syndrome, and GERD.
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