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Nicotine Electronic Cigarettes for Smoking Cessation
Am Fam Physician. 2025;111(3):210-211
Author disclosure: No relevant financial relationships.
DETAILS FOR THIS REVIEW
Study Population: 27,235 individuals who actively smoke tobacco from 88 studies, including 47 randomized controlled trials (RCTs)
Efficacy End Points: Smoking cessation at least 6 months after the start of the intervention
Harm End Points: Any adverse events or serious adverse events at least 1 week after the start of the intervention
| Benefits | Harms |
|---|---|
| Nicotine e-cigarette use vs non-nicotine e-cigarette use | |
| 1 in 34 achieved smoking cessation at 6 months to 1 year | No apparent difference in harms |
| Nicotine e-cigarette use vs nicotine replacement therapy | |
| 1 in 25 achieved smoking cessation at 6 months to 1 year | No apparent difference in harms |
| Nicotine e-cigarette use vs other smoking cessation treatments (eg, behavioral support only or no support) | |
| 1 in 25 achieved smoking cessation at 6 months to 1 year | 1 in 7 experienced adverse events from 12 weeks to 6 months |
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